| Certification: | GMP |
|---|---|
| Grade Standard: | Medicine Grade |
| Type: | API |
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Lincomycin Hydrochloride - White Crystalline Powder This esteemed compound presents itself as a pristine white crystalline powder at ambient conditions, exuding a subtle, distinctive odor with a notably bitter taste. It exhibits excellent solubility in water and methanol, ensuring versatile applications. Typically, its hydrochloride salt form is utilized in feed. Lincomycin hydrochloride originates from the prolific growth of the Streptomyces genus, particularly Streptomyces lincolnensis, classifying it under the esteemed lincosamides category of alkaline antibiotics.
| Basic Information | |
| Product name | Lincomycin Hydrochloride |
| Grade | Pharmaceutical Grade |
| Appearance | White crystal powder |
| Assay | 99% |
| Shelf life | 3 Years |
| Packing | 25kg/drum |
| Condition | stored in a cool and dry place |
Lincomycin Hydrochloride is a powerful ally in combating infections instigated by Gram-positive bacteria, especially those resilient to penicillin. It is pivotal in addressing poultry respiratory ailments caused by Mycoplasma, swine enzootic pneumonia, and anaerobic infections like chicken necrotizing enterocolitis.
Additionally, it offers therapeutic benefits for treponema dysentery, toxoplasmosis, and actinomycosis, particularly in canine and feline patients.
Lincomycin, a distinguished lincosamide antibiotic, is derived from Streptomyces lincolnensis. Its close relative, clindamycin, is synthesized by substituting the 7-hydroxy group with a different atom, resulting in an inverted chirality transformation.
Despite sharing structural similarities and antimicrobial traits with macrolides, lincomycin exhibits a broader spectrum, effectively targeting actinomycetes, mycoplasma, and certain Plasmodium species. A single intramuscular injection of 600 mg achieves peak serum concentrations of 11.6 micrograms/ml within an hour, sustaining therapeutic efficacy for 17 to 20 hours against most susceptible Gram-positive organisms. Post-dose urinary excretion ranges from 1.8% to 24.8%, averaging at 17.3%.
1. Oral forms are adept at treating respiratory infections, abdominal infections, and infections of the female reproductive tract. They are also effective against pelvic infections, as well as skin and soft tissue infections, particularly those caused by sensitive strains of Staphylococcus aureus and Streptococcus pneumoniae.
2. Beyond oral applications, injectable formulations are ideal for managing severe infections due to streptococcus, pneumococcus, and staphylococcus. They are indispensable in surgical adjuvant therapy for septicemia, bone and joint infections, chronic conditions, and acute hematogenous osteomyelitis induced by staphylococcus.
3. Lincomycin hydrochloride offers a crucial alternative for patients with penicillin allergies or those unsuitable for penicillin-type drugs, providing effective treatment for infectious diseases.
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