Furantoin is also known as furantoin, furantoin, nitrofurantoin, nitrofurantoin, chemical name 1 - [(5-nitro-2-furanyl) methylene] amino] - 24-imidazolidinedioe. It is a synthetic antibacterial drug with a broad antibacterial spectrum and has antibacterial effects on most gram positive and negative bacteria, such as Staphylococcus aureus, Escherichia coli, Staphylococcus albicans and Streptococcus pyogenes. Clinically, it is often used for urinary system infection caused by sensitive bacteria, such as Mengyu nephritis and urinary tract infection. Cystitis and prostatitis.
| TEST |
SPECIFICATION |
RESULT |
| Appearance |
A yellow crystalline powder |
Conforms |
| Identification |
A. Carry out the test protected from bright light.Use the solution prepared for the assay.
Examined between 220nm and 400nm(2.2.25),the solution shows two
absorption maxima, at 266nm and 367nm.The ratio of the absorbance at the maximum at
367nm to that at the maximum at 266nm is 1.36 to 1.42. |
Conforms |
B. Dissolve about 10mg in 10ml of dimethylformamide R. To 1ml of the solution
add 0.1ml of 0.5M alcoholic potas sium hydr oxide. A brown colour develops. |
Conforms |
| Related substances |
Not more than 1.0% |
Conforms |
| Loss on drying |
Not more than 1.0%. |
0.28% |
| Sulphated ash |
Not more than 0.1%. |
0.05% |
| Assay |
98.0~102.0%. |
99.20% |
Application of Nitrofurantoin
Nitrofurantoin has been available for the treatment of urinary tract infections (UTIs) since 1953. Its current uses include the treatment of uncomplicated UTIs and prophylaxis against UTIs in people prone to recurrent UTIs. Increasing bacterial antibiotic resistance to other commonly used agents, such as fluoroquinolones and trimethoprim/sulfamethoxazole, has led to increased interest in using nitrofurantoin.
Several trials comparing nitrofurantoin to other commonly used agents have shown this drug results in similar cure rates for uncomplicated UTIs.The efficacy of nitrofurantoin in treating UTIs combined with a low rate of bacterial resistance to this agent makes it one of the first-line agents for treating uncomplicated UTIs as recommended by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.Nitrofurantoin is not recommended for the treatment ofpyelonephritis,prostatitis and intra-abdominal abscess,because of extremely poor tissue penetration and low blood levels. It is used in the treatment of infections caused by these organisms.
Function of NitrofurantoinThe mechanism of action of nitrofurantoin is unique and complex. The works by damaging bacterial DNA, since its reduced form is highly reactive.This is made possible by the rapid reduction of nitrofurantoin inside the bacterial cell by flavoproteins
(nitrofuran reductase) to multiple reactive intermediates that attack ribosomal proteins, DNA,respiration, pyruvate metabolism and other macromolecules within the cell. Nitrofurantoin exerts greater effects on bacterial cells than mammalian cells because bacterial cells activate the more rapidly. It is not known which of the actions of nitrofurantoin is primarily responsible for its bactericidal activity. The broad mechanism of action for this likely is responsible for the low development of resistance to its effects, as the drug affects many different processes important to the bacterial cell.
Hebei Huanwei Biotech Co.,Ltd was established in 2016 and located in Shijiazhuang, Hebei Province, China. Our advantage raw material products are widely used in pharmaceutical and food industry, such as Vitamins,Nutritional Ingredients, Food Additives,Dietary Supplements, Amino Acid, APIs and so on. Besides, we supply OEM/ODM products of Dietary-supplement, including Softgel, Tablet, Hard Capsule, Functional Beverage, Gummy and others.
Huanwei Biotech has obtained the certification of ISO9001, ISO14001, ISO45001 and have been awarded Ecovadis Bronze Medal in 2023. At present we have been supplying products and services to customers in more than 20 countries in Europe, North America, South America, Africa, Southeast Asia, etc.
Q1: Are you a factory or a trading company?
A1: We are a trading company which built in 2016, our main sales staff have many years industry experience.
Q2: How do you control the quality?
A2:
1. We only select high-quality material from famous manufacturers.
2. We have a standardized production process with traceable records
3. We're certified by ISO9001 and ISO22000 Quality management system.
Q3: Can I get samples?
A3: Yes, we can supply specified quantity free sample, you pay for the freight charge only.
Q4: Which documents can you provide?
A4: We can supply Commercial Invoice, Packing List, Country of Origin, Insurance Policy, Bill of loading, COA, MSDS, and so on.
Q5: What Payment terms do you accept?
A5: T/T, L/C, D/P etc.
Audited Supplier 
){kind=link}